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    STUDIA BIOLOGIA - Issue no. 2 / 2011  
         
  Article:   EVALUATION OF THE INHIBITORY EFFECTS OF STATINS ON BLOOD VESSEL DEVELOPMENT – PROSPECTS FOR ANTIANGIOGENIC THERAPY OF CANCER.

Authors:  RAMONA MARIA MAXIM, MARIUS COSTEL ALUPEI, SEPTIMIU TRIPON, MANUELA BANCIU. 		 
       
         
  Abstract:  Statins have a primary activity related to cholesterol lowering in cardiovascular diseases. Besides their main pharmacological action, statins have pleiotropic activities with possible harmful effects on processes associated with tumor development: angiogenesis, inflammation, and metastasis. The present work has shown the effects of statins on formation of blood vessels in a chicken chorioallantoic membrane (CAM) model in vivo. Statins have been selected based on their potency to reduce cholesterol levels in blood in the following order simvastatin> lovastatin> pravastatin. The inhibitory effects of statins on vasculature development might be a promise for their future application in anticancer antiangiogenic therapy.

Keywords: angiogenesis, CAM assay, statins 		 
         
     
         
         
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