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    STUDIA BIOLOGIA - Issue no. 2 / 2004  
         
  Article:   ASPECTE ULTRASTRUCTURALE ADENOHIPOFIZARE PRIVIND EFECTUL PROTECTOR AL UNOR COMPUŞI ANTIOXIDANŢI ╬N NEUROTOXICOZA INDUSĂ DE L-GLUTAMATUL MONOSODIC LA ŞOBOLANII ALBI JUVENILI.

Authors:  CONSTANTIN PUICĂ, AHMAD MOUSA BASHA, CONSTANTIN CRĂCIUN.
 
       
         
  Abstract:  Ultrastructural Pituitary Aspects Regarding the Protective Effect of Some Antioxidants Compounds Against L-Monosodium Glutamate Induced Neurotoxicosis in White Juvenile Rats. L-monosodium glutamate (MSG) is the most abundant of a group of endogenous amino acids in the mammalian central nervous system (CNS), and in the past decade, MSG has become videly accepted as a major neurotransmitter in the vertebrate CNS. Under certain abnormal conditions as: chronic neurodegenerative disorders or following oral intake, when the concentration of this neurotransmitter rises above this level, this amino acid can be neurotoxic. At higher concentrations in the brain, the neurons are excited to death. In these conditions MSG are called excitotoxin. The administration of MSG at prepubertal stage on rodents induces alteration of hypothalamus and pituitary morphology and functionality, and severe structural and functional alterations in hypothalamic-pituitary axis. In the last decade, an considerable interest has been generated concerning the use of natural compounds, anti-oxidants in particular, in neuroprotection, against MSG excitotoxicity. Our results show that 30 day-administered of 0,17 mg/g b.w. of MSG during the juvenile, prepubertal phase of development, caused ultrastructural alterations in the pituitary structure (cytoplasmic balloonisation, intense modification of the form and size of the nuclei, mitochondrial vacuolisation, enlargement of endoplasmic reticulum). Some certain protective effects of the antioxidant micronutrients treatment, against MSG administration, upon pituitary ultrastrure, were registered.  
         
     
         
         
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