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    STUDIA BIOLOGIA - Issue no. 2 / 2003  
         
  Article:   EFECTE STRUCTURALE ŞI ULTRASTRUCTURALE DETERMINATE DE VENINUL DE ALBINE ╬N MIOCARD.

Authors:  ADRIAN FLOREA, CONSTANTIN PUICĂ, MARIUS C. OPREA, PANTE GHERGHEL, CONSTANTIN CRĂCIUN.
 
       
         
  Abstract:  Structural and Ultrastructural Effects Produced by the Honey Bee Venom in Myocardium. The honey bee (Apis mellifera L.) venom has been reported to cause very powerful effects on the heart muscle. Even when it is subcutaneously injected, the bee venom is able to cross (or to break) the vascular endothelium and to get, through the systemic circulation, in the heart. We investigated the histological and ultrastructural modifications induced in the rat myocardium after experimental administrations of the water-soluble fraction of the crystallised bee venom. The results indicate severe and dose-dependent alterations in the structure of the cardiac tissue, with oedema and haemorrhages and zonal necrosis. Alterations also occur in the fine ultrastructure of the blood vessels and, most importantly, of the myocardium cells. The nucleus, mitochondria and the sarcoplasmic reticulum strongly respond to the bee venom and important disturbances could also be noted in the pattern of sarcomeres.  
         
     
         
         
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