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    STUDIA BIOLOGIA - Issue no. 1 / 2019  

Authors:  AMY K. SCHMID.
  Abstract:  Relative to the other domains of life, few transcription factors and the genes they control in response to stress have been functionally characterized in Archaea. To understand these mechanisms, we use a systems biology approach that integrates genome-wide datasets and quantitative phenotype data into predictive computational models. Such an approach characterizes the function of key global regulators and reveals how transcription factors work together to coordinate stress responses in Halobacterium salinarum. For example, the activity of stress-resistance and growth-response transcriptional control networks were strongly anticorrelated, suggesting a lifestyle trade-off. Here we describe the underlying transcriptional mechanisms regulating each network with a focus on the regulation of metabolism, oxidative stress, and cell division. Comparison of these transcription networks to homologous systems in other halophilic species reveals surprising functional divergence among closely related species, but conserved regulatory network architecture and dynamics with distant relatives.

Keywords: Archaea, Halobacterium salinarum, stress response, transcription factors.
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