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In this paper, we consider a recently developed p53 model which simulates interactions between the proteins p53, Mdm2, Atm and DNA damage signal. We apply analytic methods to answer this question: how can the Atm protein contribute positively in DNA healing process? Indeed, we determine regions of parameters into which the Atm protein can switch off damage signals, or conversely, it can lead DNA to a permanent damage.

Keywords: DNA healing; Mdm2 protein; Atm protein