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    STUDIA BIOLOGIA - Issue no. 1 / 2003  
         
  Article:   ATENUAREA MODIFICĂRILOR STRUCTURALE ŞI METABOLICE INDUSE DE EXCESUL GLUCOCORTICOIDIC PRIN ADMINISTRAREA DE PROPRANOLOL.

Authors:  ERIKA KIS.
 
       
         
  Abstract:  Attenuation of the Glucocorticoid Excess-Induced Structural and Metabolic Disorders by Propranolol. It has been established that topical glucocorticosteroids, widely used for dermatological treatments, have a high rate of transcutaneous penetration and once absorbed into systemic circulation they produce unwanted secondary systemic side effects. As resulted from our preliminary experiments, a short-term epicutaneous treatment with Fluocinolone-acetonid N in various age groups of young rats induces structural and ultrastructural modifications of hypothalamo-pituitary-adrenal (HPA) axis. Alteration of HPA axis functions was accompanied by metabolic disorders, characteristic for steroid-diabetogenic state. Some of the structural modifications of HPA axis, according to our recent observations, are reducible by in vivo β-adrenoreceptor blockage with Propranolol. Starting from the above findings, we investigated, in parallel with the HPA axis reactions, the modifications of some metabolic parameters in prepubertal and pubertal rats, after a short-term epicutaneous treatment with Fluocinolone-acetonid N ointment, applied alone or associated with Propranolol.  
         
     
         
         
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