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    STUDIA BIOLOGIA - Issue no. 1 / 2001  
         
  Article:   FUNCTIONAL AND ULTRASTRUCTURAL EFFECTS OF CLOFIBRIC ACID ADDITION TO ISOLATED MITOCHONDRIA AND PERFUSED LIVER OF RAT AND GUINEA PIG.

Authors:  CORNELIU TARBA, CONSTANTIN CRĂCIUN, CORINA L. ROȘIORU, IOAN PETRESCU, PANTE GHERGHEL, VERONICA CRĂCIUN. 		 
       
         
  Abstract:  If concentrations of clofibric acid between 0.05 and 0.2 mM are added to isolated mitochondria or to the perfused liver of either rat or guinea pig, there are certain similar functional and ultrastructural effects in the two species, such as moderate uncoupling of oxidative phosphorylation, inhibition of both gluconeogenesis and ketogenesis, mitochondrial swelling, the presence of nuclei with an irregular outline and the disappearance of lipid droplets in the hepatocytes. However, the extents of the effects, at least in some cases, are different. While in isolated mitochondria the differences are generally small, they become more obvious in the perfused liver. For example, clofibric acid inhibits gluconeogenesis stronger in rat liver, while ketogenesis is inhibited stronger in guinea pig liver. Certain additional features can also be observed in the case of the perfused guinea pig liver, especially a beginning of cytoplasm vacuolisation, dilation of the perinuclear spaces and of the biliary canaliculi.  
         
     
         
         
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