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    STUDIA BIOLOGIA - Issue no. 1 / 2001  
         
  Article:   DOES A SINGLE THERAPEUTIC DOSE OF CYCLOPHOSPHAMIDE INDUCE THE APOPTOSIS OF THE LYMPHOCYTES ?.

Authors:  CRISTINA PAŞCA, VIOREL MICLĂUŞ, ERIKA KIS, VICTORIA-DOINA SANDU, IONEL PAPUC.
 
       
         
  Abstract:  Among alkylating agents, Cyclophosphamide is a chemo-therapeutic drug widely used in the treatment of many malignant and autoimmune diseases. Apoptosis is recognised as being the main type of cellular death observed during the evolution, which allows the exact regulation of the cell number. Generally, apoptosis is welcome for the organism, but its inadequate activation leads to different pathological states. Our histological investigations intended to emphasise the apoptotic effect of a single therapeutic dose of Cyclophosphamide on the lymphocytes in the spleen during 21 days after the chemotherapy. Our results demonstrate that, at the cellular level, Cyclophosphamide may selectively affect the mature lymphocytes and their precursor cells. Its apoptotic effect could be noticed even after 24 hours since the treatment. This effect had a zonal character, some cellular clones being more quickly affected than others. The apoptotic processes occurred in a different way in the two components of the spleen, the white pulp being earlier affected. Although this kind of process had a different intensity during the 21 days of the experiment, it persisted all this period of time. Histologically, the apoptotic effect consisted of the appearance of nuclear condensation, morphological changes of the cells, nucleolar distorsions, nuclear and cell fragmentation.  
         
     
         
         
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