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Changes in Groundwater Quality by Urban Area Development: Case Study of Aquifers in Tehran Plain, Iran. The objective of this research is to review and study changes in ground water quality of plains induced by natural and more particularly artificial parameters. The case study concerns the Tehran Plain, for which the water quality maps (Iso-chlorine, electrical conductivity and total dissolved solids in groundwater) over a period of 25 years (1981 – 2006) and compared to each other. Furthermore the 16 years (1990 – 2006) chemical analyses of a number of wells in the plain were also available. The sample wells were selected in the east, west, north and south of Tehran for the purpose of studying changes in chlorine(CL) concentration, electrical conductivity (EC) and total dissolved solid(TDS) in time. The results show a general increase of the mentioned anions in groundwater, with chlorine concentration increasing from a minimum of 15 to a maximum of 76 mg/l; EC from a minimum of 212 to a maximum of 731 micro-mohs/ cm2 and the TDS from a minimum of 0 to a maximum of 146 mg/l. Moreover the comparison of the typical water map reveals a gradual decline of carbonated water and an increase in sulfated and chlorinated water in the Tehran Plain over time. Based on the results the artificial parameters affecting the quality of groundwater in Tehran Plain are the uncontrolled urban expansion and consequently overexploitation of aquifers in sensitive areas, increased infiltration of wastewater from absorption wells and the increased infiltration of surface runoffs and floodwater. The results of the study can be applied in urban planning and management of aquifers affected by urban development.