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Rezumat articol ediţie STUDIA UNIVERSITATIS BABEŞ-BOLYAI
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Rezumat: Aims: The influence of acute O3 and hypobaric hypoxia exposure on the serum oxidant/antioxidant balance under rest and exercise conditions was studied. Material and methods: The research was performed in 5 groups of white male Wistar rats (n = 10 animals /group) with a weight of 280-300 g: Group I – control group, sedentary rats under normoxia conditions; Group II – sedentary rats, acutely exposed to O3; Group III – animals acutely exposed to O3, followed by exercise under normoxia conditions; Group IV – sedentary rats exposed to acute combined stress: acute O3 + hypobaric hypoxia (corresponding to a 2500 m altitude); Group V – animals exposed to acute combined stress (acute O3 + moderate hypoxia), followed by exercise (under normoxia conditions). The exposure to moderate hypoxia was for 3 days, 20 hours/day at values of 2500 m using hypoxic rooms. The rats were exposed to ozone for 3 days, 5 min/day. Groups III and V were trained daily for 3 days under normoxia conditions by swimming. In order to determine the indicators of the oxidant/antioxidant balance, venous blood samples were taken from the retro-orbital sinus. In the third day were determined: malondialdehyde (MDA), protein carbonyls (PC), hydrogen donor capacity (HD) and total sulfhydryl (thiol) group content (SH). Rezults: that acute exposure to combined stress: O3 and hypobaric hypoxia influences the serum oxidant/antioxidant (O/AO) balance, with the increase of oxidative stress (OS) on account of PC in sedentary animals (group IV) compared to controls, and stimulates the AO defense capacity on account of HD in both sedentary animals (group IV) and animals undergoing physical exercise (group V) compared to the controls. Conclusions: Acute O3 and hypobaric hypoxia exposure causes an increase in OS on account of MDA and PC in sedentary animals. Physical exercise after acute O3 and hypobaric hypoxia exposure determines, compared to sedentary animals exposed to the same factors, an increase in AO defense on account of HD and a decrease in AO on account of SH groups. Associated O3 and hypobaric hypoxia exposure has modulatory effects on the serum O/AO balance in sedentary animals and animals undergoing physical exercise.
Keywords: acute exposure, hypobaric hypoxia, ozone, oxidant/antioxidant balance, effort.
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