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    STUDIA CHEMIA - Ediţia nr.4 din 2018  
         
  Articol:   COMPARATIVE CYTOTOXICITY ASSAYS PERFORMED USING A FREE PORPHYRIN AND ITS Zn(II), Co(II) AND Cu(II) COMPLEXES. INFLUENCE OF OPTICAL AND AGGREGATION PROPERTIES.

Autori:  RADOSTINA ALEXANDROVA, RENI KALFIN, RAMONA TUDOSE, EUGENIA FAGADAR-COSMA.
 
       
         
  Rezumat:  
Our present approach is dealing with comparative cytotoxicity assays performed with a porphyrin base, substituted with methoxy-inductive donor substituents in the meso position, namely: 5,10,15,20-tetrakis-(p-methoxy-phenyl porphyrin (TMeOPP) and with its Zn(II), Co(II) and Cu(II) complexes (Figure 1). The cytotoxicity evaluation was performed using human (HeLa, 8 MGBA, Lep-3) and bovine (MDBK) cell lines as model systems. The influence of the compounds on cell viability and proliferation was studied by (thiazolyl blue tetrazolium bromide) MTT test and further discussed taking into consideration the main optical and aggregation properties of the free porphyrin and its different metal complexes.

Keywords: Zn(II), Co(II) and Cu(II)-metalloporphyrins, cytotoxicity evaluation, UV-vis spectroscopy, STEM microscopy, MTT test.
 
         
     
         
         
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