Rezumat articol ediţie STUDIA UNIVERSITATIS BABEŞ-BOLYAI

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1,4-benzoquinone guanyl-hydrazone thiosemycarbazone (Ambazone) is an antimicrobial compound, usually employed in Faringosept drug preparation. During the Ambazone synthesis some secondary products appear. One of these secondary products - (1,4-benzoquinon-guanyl-semycarbazone - BGHS) has a chemical structure similar to Ambazone one. In order to investigate the monohydrate and anhydrous forms of Ambazone and of BGHS several techniques were employed such as: powder X-ray diffraction (PXRD), Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC) analysis. It was established that the ambazone monohydrate crystallizes in monoclinic system having P21/c space group. Details of the structures and spectroscopic properties for studied compounds are discussed. The stretching vibrations of primary and secondary amine have been identified by FTIR spectroscopy and showed changes in their characteristic absorption regions during water loss upon heating the ambazone monohydrate sample at 140C. In the dehydration process, a change in molecular rearrangement was evidenced and the anhydrous ambazone was obtained. DSC data confirm the water molecules loss after 37.5 min. of heating treatment at 140^oC and XRPD indicates a new crystalline phase.

Keywords: ambazone, BGHS, PXRD, DSC, FTIR