AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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STUDIA CHEMIA - Ediţia nr.4 din 2007 | |||||||
Articol: |
SPECTROPHOTOMETRIC STUDIES OF DIAZEPAM - ß-CYCLODEXTRIN COMPLEX FORMATION. Autori: IRINA KACSO, IOAN BRATU, ANDREEA FARCAS, MARIUS BOJITA. |
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Rezumat: Solid state interactions between a bioactive substance-Diazepam and ß-cyclodextrin (ß-CD) - the so called inclusion compounds (obtained by different preparation methods: kneading, co-precipitation and freeze-drying) were investigated. The obtained compounds were investigated by FTIR spectroscopy to evidence their formation. The results revealed that the solid state inclusion compound, such as Diazepam/ß-cyclodextrin has a good stability. The stoichiometry of the inclusion complexes of diazepam with ß-CD is 1:1 was investigated in solution. The association constant of the complex was determined by UV spectrophotometry. The encapsulation might improve Diazepam stability and bioavailability of the drug. | |||||||