AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
Rezumat articol ediţie STUDIA UNIVERSITATIS BABEŞ-BOLYAI
În partea de jos este prezentat rezumatul articolului selectat. Pentru revenire la cuprinsul ediţiei din care face parte acest articol, se accesează linkul din titlu. Pentru vizualizarea tuturor articolelor din arhivă la care este autor/coautor unul din autorii de mai jos, se accesează linkul din numele autorului.
Autori: DORU GEORG MARGINEANU.
DOI: 10.24193/subbchem.2021.3.01
Published Online: 2021-09-30
Published Print: 2021-09-30
pp. 49-62
VIEW PDF
FULL PDF
Neuropharmacology (NP), which evolved along with scientific medicine, got treatments for several common disorders of the nervous system. But, most of the NP drugs are just symptomatic, reducing only the manifestations of brain pathologies. Also, for main neuro-psychiatric pathologies (e.g. the neurodegenerative diseases) there is very poor or no medication, and the output of NP drug discovery declined in the last decades. This review paper argues that those drawbacks derive from the reductionist NP leaning towards single–target selective drugs, at odds with the essential complexity of brain functioning and the multifactorial causality of its pathologies. Most active neuro-drugs (e.g. valproate and levetiracetam) are in fact multi-mechanistic since they have been selected by phenotypic screening in vivo, not by single-target binding in vitro. A putative solution of the relative NP stagnation seems to come with the emergent systemic approach of network pharmacology. A plausible flowchart of the main stages of a network NP drug discovery endeavor is finally sketched.
Keywords: brain complexity, systems biology, network pharmacology, magic bullet, magic shotgun, multi-mechanistic drug, valproate, levetiracetam, multi-potent drug, poly-therapy
