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    STUDIA CHEMIA - Ediţia nr.3 din 2014  
         
  Articol:   C REACTIVE PROTEIN LEVEL AS A DIAGNOSE TEST FOR SLEEP APNEA-HYPOPNEA SYNDROME.

Autori:  . 		 
       
         
  Rezumat:   ABSTRACT. Sleep apnea-hypopnea syndrome is a disease characterized by repetitive episodes of partial or total collapse of the upper airways during sleep. The collapse of the upper airways and the repeated nocturnal desaturations of arterial blood in this disease lead to the development of chronic low-grade systemic inflammation, contributing to the pathogenesis of cardiovascular diseases. C-reactive protein is an inflammatory marker with pentameric structure that migrates electrophoretically in the gamma vicinity. The present study has aimed to determine the diagnostic ability of CRP levels for SAHS in order to facilitate exploratory tests in sleep medicine. In order to obtain a proper diagnostic test a compromise was made between sensitivity and specificity using Receiving Operating Characteristic curve. "Area under curve" was 0,7742 for a 95% confidence interval, p= < 0,0001. CRP values < 10 mg/ l showed a less sensitive test, but very specific. CRP values > 12 mg/ l showed a very sensitive test, but the specificity decreased dramatically. We have demonstrated that CRP levels cannot be used for positive diagnosis of SAHS, because, despite high values are associated with a positive diagnosis, the specificity of the test decreases dramatically when the CRP values are higher than 13 mg/ l.

Keywords: apnea, hypopnea, polysomnography, C- reactive protein, the ROC curve
 
         
     
         
         
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