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AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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STUDIA CHEMIA - Ediţia nr.3 din 2011 | |||||||
Articol: |
IMAGISTICA INVESTIGAŢIEI SPECTROSCOPIEI RAMAN PRIVIND SISTEMUL DE CLOTRIMAZOL A PAA. Autori: CORNEL-VIOREL POP, TRAIAN ŞTEFAN, SIMION AŞTILEAN, MIHAI TODICA. |
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Rezumat: The dispersion of clotrimazole in the polyacrylic acid (PAA) matrix and the possible interaction between the drug and polymeric matrix were investigated by Raman imaging spectroscopy. The optical analysis shows an inhomogeneous distribution of the clotrimazole in the polymeric matrix. An area of 10x10 μm of the sample was scanned and a spectral image map of the most important bands was constructed. The imaging spectral map was constructed observing the intensity of the characteristic band 1045 cm-1 of clotrimazole respectively 1450 cm-1 of PAA, recorded for each point of the scanned area. The spectrum of the clotrimazole in the PAA matrix is essentially identical to the spectrum of pure clotrimazole. This indicates non interaction between polymeric matrix and clotrimazole. Keywords: PAA, clotrimazole, Raman spectroscopy |
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