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    STUDIA CHEMIA - Ediţia nr.1 din 2003  
         
  Articol:   THE SOLUBILITY OF DRUGS IN SUPERCRITICAL CO2 AND THE EFFECT OF ENTRAINERS.

Autori:  SIMION DRĂGAN, MIHAELA DRǍGAN. 		 
       
         
  Rezumat:  In this work the solubility of two drugs in supercritical carbon dioxide are being measured. There were investigated the solubility of terfenadine and griseofulvin in s.c. carbon dioxide at pressures in the range of 140 180 bar and two temperatures 313,2 K and 343,2 K. To evaluate the solubility of the two drugs we are using an equation of Chrastil type and obtained the values for the association number k, and for the two constants a, b which take into account the enthalpy of solvation and vapourization of the solute and the molecular weight of the species. This chemicals have relatively low solubilities with values ranging from 3,092x10-7 to 1,8550x 10-6 mole fraction. The solubilities exhibit a clear dependence on the solvent density and this has been used to provide a simple and precise correlation of the data. The effect of ethanol added to CO2 as an entrainer was investigated, varying its concentration in CO2 from 1wt % to 5wt.%.  
         
     
         
         
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