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    STUDIA BIOLOGIA - Ediţia nr.2 din 2005  
         
  Articol:   MODIFICĂRI STRUCTURALE ŞI ULTRASTRUCTURALE PRODUSE ÎN GLANDELE SUPRARENALE DUPĂ ADMINISTRAREA EXPERIMENTALĂ A VENINULUI DE ALBINE (APIS MELLIFERA L.) I. GLANDELE CORTICOSUPRARENALE.

Autori:  ADRIAN FLOREA, CONSTANTIN CRĂCIUN, CONSTANTIN PUICĂ.
 
       
         
  Rezumat:  Structural and Ultrastructural Changes Produced in Adrenal Glands Consequently to the Honey Bee Venom Experimental Administration. I. The Adrenal Cortex. We have previously reported significant changes produced in different tissues including hypothalamus after the honey bee (Apis mellifera L.) venom subchronic treatments. In this study we investigated the histological and ultrastructural aspects of the adrenal cortex after the venom administration in the same conditions. The histological results indicate an important impairment of the gland, particularly of zona fasciculata, associated with hyperemia, zonal necrosis, and a general disturbance of cells pattern, aspect and their sizes. A wide range of alterations, from small morphological changes to cell lysis, also occur in the fine ultrastructure of the secretory cells. However, the main features of these cells are the decreased number of the secretory vesicles and their heterogenous aspect. The general aspect is characteristic for the prolonged stress conditions and indicates a sustained activity of hormone secretion. Most of the capillaries are dilated and endothelial cells damaged. These findings provide evidence that the enhancement of secretory activity in hypothalamus, induced by the bee venom, is reflected upon the structure and physiology of the adrenal cortex, but also a direct action of the venom molecules on this gland is obvious.  
         
     
         
         
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