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AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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STUDIA BIOLOGIA - Ediţia nr.1 din 2007 | |||||||
Articol: |
ULTRASTRUCTURAL STUDIES CONCERNING THE REACTIVITY OF THE HIPOTHALAMIC-PITUITARY AXIX FOLLOWING L-MONOSODIUM GLUTAMATE ADMINISTRATION IN JUVENILE RABBITS. Autori: CONSTANTIN PUICĂ, CONSTANTIN CRĂCIUN, MIRCEA RUSU, IOANA ROMAN, MIHAI CRISTESCU. |
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Rezumat: . Subchronic oral administration for 30 days of L-monosodic-glutamate (GLU) in a daily dose of 0.15 mg/g, body weight in immature prepubertal male rabbits, induced reactive manifestations of mediobasal hypothalamus morphology, characterized by ultrastructural alteration of the majority of neuronal cellular components: nucleus, nucleolus, mitochondria and endoplasmic reticulum. The excitotoxic effect of GLU is expressed also by the blocking in some hypothalamus regions of the axonal and dendrites myelinates processes. At the adenohypophysis level, glutamate has determined drastically reduces of the number of the electron-dense secretory granules in some cellular components associated with mitochondrial balloonization, dilatation of both smooth endoplasmic reticulum and Golgi apparatus, as well as significantly rarefaction of ribosome from cytoplasmatic structure. | |||||||
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