Rezumat articol ediţie STUDIA UNIVERSITATIS BABE┼×-BOLYAI

În partea de jos este prezentat rezumatul articolului selectat. Pentru revenire la cuprinsul ediţiei din care face parte acest articol, se accesează linkul din titlu. Pentru vizualizarea tuturor articolelor din arhivă la care este autor/coautor unul din autorii de mai jos, se accesează linkul din numele autorului.

 
       
         
    STUDIA BIOLOGIA - Ediţia nr.1 din 2003  
         
  Articol:   ATENUAREA MODIFICĂRILOR STRUCTURALE ŞI METABOLICE INDUSE DE EXCESUL GLUCOCORTICOIDIC PRIN ADMINISTRAREA DE PROPRANOLOL.

Autori:  ERIKA KIS.
 
       
         
  Rezumat:  Attenuation of the Glucocorticoid Excess-Induced Structural and Metabolic Disorders by Propranolol. It has been established that topical glucocorticosteroids, widely used for dermatological treatments, have a high rate of transcutaneous penetration and once absorbed into systemic circulation they produce unwanted secondary systemic side effects. As resulted from our preliminary experiments, a short-term epicutaneous treatment with Fluocinolone-acetonid N in various age groups of young rats induces structural and ultrastructural modifications of hypothalamo-pituitary-adrenal (HPA) axis. Alteration of HPA axis functions was accompanied by metabolic disorders, characteristic for steroid-diabetogenic state. Some of the structural modifications of HPA axis, according to our recent observations, are reducible by in vivo β-adrenoreceptor blockage with Propranolol. Starting from the above findings, we investigated, in parallel with the HPA axis reactions, the modifications of some metabolic parameters in prepubertal and pubertal rats, after a short-term epicutaneous treatment with Fluocinolone-acetonid N ointment, applied alone or associated with Propranolol.  
         
     
         
         
      Revenire la pagina precedentă