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Rezumat articol ediţie STUDIA UNIVERSITATIS BABEŞ-BOLYAI
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Rezumat: The results obtained in the present study demonstrate that clofibric acid (CA) has generally stronger effects on guinea pig liver metabolism and ultrastructure than on rat. Important differences can be seen following a subchronic treatment (7 days) of the animals with clofibric acid. Thus, mitochondria isolated from treated guinea pigs display a very low respiratory control ratio (1.2-1.5), while those isolated from treated rats seem to be very little affected. Ketogenesis and, to a lesser extent, gluconeogenesis in guinea pigs are more strongly affected (inhibited) by CA treatment. The differences are also confirmed by the ultrastructural results. In the case of guinea pig, isolated mitochondria are dominated by swollen or even disintegrated organelles, along with ultracondensed ones. In the hepatic tissue, one can observe polymorphous mitochondria with a rarefied matrix, dilated perinuclear spaces, enlarged lysosomes and an increased quantity of glycogen. These changes are much less visible in the case of the rat. What is striking for the rat liver after the CA treatment is the massive presence of peroxisomes (peroxisomal proliferation). Even though animal weight decreases in both species following the CA treatment, the mechanism by which it is achieved seems to be different. In the case of rat liver, the presence of peroxisomal metabolism, enhanced by the phenomenon of proliferation, is likely to represent a protective factor against CA effects, whereas the mitochondrial metabolism in guinea pig liver remains much more exposed to the action of CA. |
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